Sunday, May 1, 2011

CrazyEngineers Forum

CrazyEngineers Forum

Borrowed and never returned

Posted: 01 May 2011 10:36 AM PDT

Some stuffs borrowed by our buddies never come back. It may be a book, a cd, an instrument or whatever.I lent some books, cd's and never got it back. My list includes: KS Joke Book, A Philosophers bio, Book on corruption, Very Historical Biography Book - as old as i cant know the name of that book. I feel bad that i lost those books.

Just think abt the books you lent and never came back, and post their names here... and even if you borrowed something and never returned it.

Name Space TCP/HTTP

Posted: 01 May 2011 09:26 AM PDT

:confused::confused::confused::confused::confused: :confused::confused::confused::confused:

HI,

PLEASE CAN ANY ONE EXPLAIN EXACTLY WHAT NAME SPACE IS ?? , I UNDERSTANT THAT FOR EASY UNDERSTANDING WE CONVERT IP: 19*.12*.1*.1* TO URL:WWW.ABC.COM FOR EASY UNDERSTANDING . I HAVE FOLLOWING QUESTIONS ON THIS

1. BUT IF THIS IS CASE HOW DNS(DOMAIN NAME SERVER IS DIFFERENT )

2.HOW IS NAME SPACE DIFFERENT FOR TCP, IP AND HTTP ?

PLEASE SOMEONE WHO IS MASTER IN IT EXPLAIN ABOVE QUESTIONS , ITS CONFUSING .

Origami Not Just for Paper Anymore: DNA, Folded Into Complex Shapes, Could Have a Big

Posted: 01 May 2011 08:10 AM PDT

While the primary job of DNA in cells is to carry genetic information from one generation to the next, some scientists also see the highly stable and programmable molecule as an ideal building material for nanoscale structures that could be used to deliver drugs, act as biosensors, perform artificial photosynthesis and more.


Trying to build DNA structures on a large scale was once considered unthinkable. But about five years ago, Caltech computational bioengineer Paul Rothemund laid out a new design strategy called DNA origami: the construction of two-dimensional shapes from a DNA strand folded over on itself and secured by short "staple" strands. Several years later, William Shih's lab at Harvard Medical School translated this concept to three dimensions, allowing design of complex curved and bent structures that opened new avenues for synthetic biological design at the nanoscale.

A major hurdle to these increasingly complex designs has been automation of the design process. Now a team at MIT, led by biological engineer Mark Bathe, has developed software that makes it easier to predict the three-dimensional shape that will result from a given DNA template. While the software doesn't fully automate the design process, it makes it considerably easier for designers to create complex 3-D structures, controlling their flexibility and potentially their folding stability.

"We ultimately seek a design tool where you can start with a picture of the complex three-dimensional shape of interest, and the algorithm searches for optimal sequence combinations," says Bathe, the Samuel A. Goldblith Assistant Professor of Applied Biology. "In order to make this technology for nanoassembly available to the broader community -- including biologists, chemists, and materials scientists without expertise in the DNA origami technique -- the computational tool needs to be fully automated, with a minimum of human input or intervention."

Bathe and his colleagues described their new software in the Feb. 25 issue of Nature Methods. In that paper, they also provide a primer on creating DNA origami with collaborator Hendrik Dietz at the Technische Universitaet Muenchen. "One bottleneck for making the technology more broadly useful is that only a small group of specialized researchers are trained in scaffolded DNA origami design," Bathe says.

Programming DNA

DNA consists of a string of four nucleotide bases known as A, T, G and C, which make the molecule easy to program. According to nature's rules, A binds only with T, and G only with C. "With DNA, at the small scale, you can program these sequences to self-assemble and fold into a very specific final structure, with separate strands brought together to make larger-scale objects," Bathe says.

Rothemund's origami design strategy is based on the idea of getting a long strand of DNA to fold in two dimensions, as if laid on a flat surface. In his first paper outlining the method, he used a viral genome consisting of approximately 8,000 nucleotides to create 2-D stars, triangles and smiley faces.

That single strand of DNA serves as a "scaffold" for the rest of the structure. Hundreds of shorter strands, each about 20 to 40 bases in length, combine with the scaffold to hold it in its final, folded shape.

"DNA is in many ways better suited to self-assembly than proteins, whose physical properties are both difficult to control and sensitive to their environment," Bathe says.

Bathe's new software program interfaces with a software program from Shih's lab called caDNAno, which allows users to manually create scaffolded DNA origami from a two-dimensional layout. The new program, dubbed CanDo, takes caDNAno's 2-D blueprint and predicts the ultimate 3-D shape of the design. This resulting shape is often unintuitive, Bathe says, because DNA is a flexible object that twists, bends and stretches as it folds to form a complex 3-D shape.

According to Rothemund, the CanDo program should allow DNA origami designers to more thoroughly test their DNA structures and tweak them to fold correctly. "While we have been able to design the shape of things, we have had no tools to easily design and analyze the stresses and strains in those shapes or to design them for specific purposes," he says.

At the molecular-level, stress in the double helix of DNA decreases the folding stability of the structure and introduces local defects, both of which have hampered progress in the scaffolded DNA origami field.

Postdoctoral researcher Do-Nyun Kim and graduate student Matthew Adendorff, both of the Bathe lab, are now furthering CanDo's capabilities and optimizing the scaffolded DNA origami design process.

Building nanoscale tools

Once scientists have a reliable way to assemble DNA structures, the next question is what to do with them. One application scientists are excited about is a "DNA carrier" that can transport drugs to specific destinations in the body such as tumors, where the carrier would release the cargo based on a specific chemical signal from the target cancer cell.

Another possible application of scaffolded DNA origami could help reproduce part of the light-harvesting apparatus of photosynthetic plant cells. Researchers hope to recreate that complex series of about 20 protein subunits, but to do that, components must be held together in specific positions and orientations. That's where DNA origami could come in.

"DNA origami enables the nanoscale construction of very precise architectural arrangements. Researchers are exploiting this unique property to pursue a number of applications at the nanoscale, including a synthetic photocell," Bathe says. "While applications such as this are still quite far off on the horizon, we believe that predictive engineering software tools are essential for progress in this direction."

Novel applications may also grow out of a new competition being held at Harvard this summer, called BIOMOD. Undergraduate teams from about a dozen schools, including MIT, Harvard and Caltech, will try to design nanoscale biomolecules for robotics, computing and other applications.

In the meantime, Bathe is focusing on further developing CanDo to enable automated DNA origami design. "Once you have an automated computational tool that allows you to design complex shapes in a precise way, I think we're in a much better position to exploit this technology for interesting applications," he says.

For DNA origami to have a broad impact, it needs to become routine to simply order up DNA parts to build any configuration you can dream up, Bathe says. He notes: "Once non-specialists can design arbitrary 3-D nanostructures using DNA origami, their imaginations can run free."

Source: Origami not just for paper anymore: DNA, folded into complex shapes, could have a big impact on nanotechnology

Instructables - Hundreds of projects on all sorts of topics

Posted: 01 May 2011 06:49 AM PDT

This sites features D-I-Y projects on chocolates to robotics. Registering for the free version is good enough for most purposes.
Technology - How to Make Instructables

Bioramani

Eligibility exam for PhD.

Posted: 01 May 2011 02:10 AM PDT

Quote:
"Better late than never," goes an adage. This can be better applied to Nagpur University that has finally decided to start an eligibility exam for the doctor of philosophy (PhD) aspirants from 2011-12 academic session. It will be conducted twice a year - on second Saturdays of January and July. NU was the only among all non-agriculture universities in Maharashtra that was not filtering PhD aspirants through such test. Even Amravati University started an aptitude test for PhD aspirants last year.

Now, vice-chancellor Vilas Sapkal has issued a Direction (No 7 of 2011) on April 18 "prescribing eligibility criteria and procedure for registration of candidates, selection of supervisors, guides and research, topics, thesis submission and its evaluation for PhD degree in all faculties," as per UGC's June 1, 2009 notification.

Registrar Mahesh Yenkie confirmed the development and stated that the Board of College and University Development (BCUD) would now frame the exam schedule and other formalities. "After this, VC would come out with an ordinance," he informed. According to the Direction, a copy of which is with TOI, postgraduate degree (masters) holders with minimum 50% marks or equivalent Grade Point Average (GPA) or 55% marks in law faculty (masters) would be eligible for the exam. There will be relaxation of 5% for the reserved category candidates.

Masters degree holders working in national laboratories/institutes/government or private organization nominated/sponsored candidates, holding the rank of assistant director, can also apply. Candidates having exceptional abilities having cleared graduation with 50% marks with 15 years experience in the relevant field would also be eligible.

The exam would have two papers of 100 marks each - General Aptitude Test and Subject Specific Test. The results of first paper would be out on NU website with the list of successful candidates selected for second paper. The advertisement for inviting applications for the test details would also be published in the newspapers twice a year - in first week of December and June. The first paper will have 100 multiple choice questions covering logical reasoning, numerical ability and language aptitude while the second one (partly descriptive) will be conducted by respective NU departments.

Interestingly, there will be an exemption from the test to the candidates qualified in GATE/NET-SET/JRF exams along with NU's MPhil graduates. Also NU's approved teachers having over five years' teaching experience at UG/PG level and scientists/officers working in the governmental organizations or national labs or research institutions would also get the exemption.

PhD entrance highlights:

* To be based on tough Pune pattern

* To be held in Jan and July every year

* Masters having 50% marks or GPA can apply

* To have two papers of 100 marks each

* Exemption to GATE/NET-SET/JRF cleared candidates
Source: NAGPUR UNIVERSITY: Now, a test for doing PhD

techfest of new college

Posted: 01 May 2011 12:55 AM PDT

Hey guys this year my college will be holding its first tech fest need help getting sponsors and we want to make a name for the college so what can we do so that it becomes a huge event.
We need 5lakh from sponsorship :)
waiting for your suggestions

difference between all the languages..........

Posted: 01 May 2011 12:31 AM PDT

hey, can anyone divide or classify all the languages in different sections and provide the basic differences between them??? this thread may be very helpful for all the newbies..............

Yahoo Mail Beta Vs. Gmail: Which Is Better?

Posted: 30 Apr 2011 11:51 PM PDT

Taking lessons from Gmail's simplicity and speed, Yahoo recently rolled out the new version of the Yahoo Mail (beta) to all its users. If you have tried the new Yahoo Mail, you will agree with me that it looks really cool to eyes and is fast as well. Plus Yahoo messenger is integrated just like Gtalk in Gmail. This brings us to know what our CEans think about both these email services.

I personally like the look of new yahoo mail beta more than Gmail. If you select proper theme, the colors looks gorgeous in Yahoo mail beta. The speed of operations is fast as well. The gmail, on the other hand is simple - it gives you the inbox as soon as you are logged in.

I personally don't like the advertisement integration in Yahoo Mail. Otherwise, I believe it's got an edge over the Gmail. In terms of functionality, however, Gmail Labs give gmail a huge advantage over any other email service out there. I however do not use gamil labs apps so it doesn't make a huge difference to me.

What's your opinion?

Standard Size in SI

Posted: 30 Apr 2011 11:17 PM PDT

I just want to know what is the standard size in SI of the following:
1. Dining Room
2. Bedrooms
3. Master Bedroom
4 Master Bath
5. Kitchen
6. Bathrooms
7. Living room
8. Utility room
9. Hallways

Can somebody Suggest me a mobile model for these requirements.,

Posted: 30 Apr 2011 10:58 PM PDT

I'm planning to buy android smart phone, I have very less knowledge about the andriod smart phones,

following are my requirements.,

1) I want to check microsoft office outlook exchange mail often, it would be better if that app gives me a alert sound when the mail arrives.
2)Fast processing
3)Full Touch Screen
4)better battery life time and call quality

Can somebody give the model no and price of that.,
PS:- If these requirements are available na enouch for me, cheaper mobile is available?

AIEEE 2011 Paper Leaked?

Posted: 30 Apr 2011 10:54 PM PDT

There is a rumor that the AIEEE paper has been leaked. The news I heard is that AIEEE paper was leaked at some center in Uttar Pradesh (UP) India. The sites are reporting that the paper was being sold in open market in Lucknow.

If you have more information about the leak, please report it in this discussion thread.

Update: Zee News -

The exam, which is held in two parts, is now expected to start at 12:00 noon. The second paper, which was scheduled for the noon session from 2.00 pm to 5.00 pm, will now be held from 4.00 pm to 7.00 pm.
The exam was delayed after a leaked question paper was recovered by the Uttar Pradesh STF from Kanpur.

CrazyFile Quadrocopter Project By Daedalus

Posted: 30 Apr 2011 09:45 PM PDT

The daedalus projects has created this tiny crazyfile quadrocopter that rocks. For the details of the project, visit following link: CrazyFlie quadcopter description « Daedalus Projects

Check out following video -

Is there any framework for software development in java ?

Posted: 30 Apr 2011 09:36 PM PDT

Hello friend's
As we know there are some frameworks which easy our task of coading management.I have some read about struts framework of java which is a nice framework for web development.But i want to know is there any framework which is used for software development ?

Game Playing Kids - Surrogate Defence Software Developers

Posted: 30 Apr 2011 06:40 PM PDT

Dangerous waters

Will game players be used to develop and fine tune actual software for warfare?

Dangerous waters | Opinion | The Engineer
The game itself is here:
https://actuv.darpa.mil/

Bioramani

AirTel Or Nokia For Summer Internship?

Posted: 30 Apr 2011 01:13 PM PDT

sir if i am in 3rd year b.tech ece....for my 6 weeks summer training..which would be better airtel ( or other service providers) or nokia etc.?
i m really interested in mobile communication...and also doing a project on the same...
Posted by at

No comments:

Post a Comment

Subscribe to: Post Comments (Atom)